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When Cell Avidity insights would have prevented clinical trial failure: the APRIL-CAR retrospective

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Abstract

Interestingly, 8 out of 10 CAR T lead candidates fail after preclinical development. This suggests that current preclinical in vitro assays insufficiently predictive. This status quo could worsen as the field moves into tackling more challenging targets such as solid tumors, which require more sophisticated next generation designs like dual-targeting, logic-gating or BiTE-secreting CARs. However, implementing Cell Avidity analysis at an early stage in the drug development process can help to identify superior lead candidates and improve (pre)clinical correlation, as shown by this study.

What you'll learn

Collaborators

Lydia Lee, PhD
Group Leader - Myeloma Immunotherapy
University College London

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