Publications

Dynamic Single-Molecule
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Extracellular domain 2 of TSPAN4 governs its functions

Dharan, R. et al.
2024
Biophysical Reports
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Mechanobiology
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Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures

Dai, X. et al.
2021
Nature Communications
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Identification and correction of miscalibration artifacts based on force noise for optical tweezers experiments

Freitag, M. et al.
2021
J. Chemical Physics
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Experimental study of a nanoscale translocation ratchet

Molcrette B, et al.
2022
PNAS
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Supported Natural Membranes on Microspheres for Protein–Protein Interaction Studies

Cheppali S.,
2022
ACS Appl. Mater. Interfaces
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Cytoskeletal Structure and Transport
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Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes

Dharan R.,
2023
Nature Communications
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Cytoskeletal Structure and Transport
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Membrane Tension Inhibits Lipid Mixing by Increasing the Hemifusion Stalk Energy

Shendrik, P. et al.
2023
ACS Nano
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Cytoskeletal Structure and Transport
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Efficient optical plasmonic tweezer-controlled single-molecule SERS characterization of pH-dependent amylin species in aqueous milieus

Wenhao Fu, et al.,
2023
Nature Communications
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A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D

Stadler R. et al.,
2022
eLife
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Single Cell Reactomics: Real‐Time Single‐Cell Activation Kinetics of Optically Trapped Macrophages

Vasse, G. F. et al.
2021
Small Methods
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Mechanobiology
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3D nanofabricated soft microrobots with super-compliant picoforce springs as onboard sensors and actuators

Xu, H. et al.,
2024
Nature Nanotechnology
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Single cell force spectroscopy of erythrocytes at physiological and febrile temperatures reveals mechano-modulatory effects of atorvastatin

Sheikhhassani, V.  et al.,
2022
Soft matter
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Mechanobiology
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Single-cell analysis reveals chemokine-mediated differential regulation of monocyte mechanics

Evers, T. M. J. et al.
2022
iScience
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Mechanobiology
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Single-Cell Mechanical Characterization of Human Macrophages

Evers T. et al.,
2022
Advanced Nanobiomed Research
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Mechanobiology
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Weak catch bonds make strong networks

Mulla, Y. et al.
2022
Nature Materials
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Mechanobiology
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Microtubule Lattice Spacing Governs Cohesive Envelope Formation of Tau Family Proteins

Siahaan, V. et al.
2022
Nature Chemical Biology
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Mechanobiology
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Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature

Dharan R. et al.,
2022
PNAS
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Mechanobiology
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Directed assembly of genetically engineered eukaryotic cells into living functional materials via ultrahigh-affinity protein interactions

Quikun Y. et al.,
2022
Science Advances
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Mechanobiology
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Mechanics of serotonin-producing human entero-endocrine cells

Evers, T.M.J. et al.
2024
Mechanobiology in Medicine
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Mechanobiology
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Probing Local Force Propagation in Tensed Fibrous Gels

Goren S. et al.,
2022
Small
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Mechanobiology
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Construction of multiphasic membraneless organelles towards spontaneous spatial segregation and directional flow of biochemical reactions

Zhorabek F. et al.,
2023
Chemical Science
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Mechanobiology
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Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue

Cheng Lyu et al.,
2023
Nature Biomedical Engineering
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Mechanobiology
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Cell protrusions and contractions generate long-range membrane tension propagation

De Belly, H. et al.
2023
Cell
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Mechanobiology
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Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function

Liu, D. et al.
2023
Nature Immunology
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Mechanobiology
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Determination of single-molecule loading rate during mechanotransduction in cell adhesion

Jo, M.H. et al.
2024
Science
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Mechanobiology
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Single-cell analysis of innate immune cell mechanics: an application to cancer immunology

Evers, T.M.J. et al.
2024
Material Advances
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Mechanobiology
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Rethinking the relationships between gel like structure and sludge dewaterability based on a binary gel like structure model: Implications for the online sensing of dewaterability

Zhang, D. et al.
2024
Water Research
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Mechanobiology
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Micro-tensile rheology of fibrous gels quantifies strain-dependent anisotropy

Goren, S. et al.
2024
Acta Biomaterialia
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Mechanobiology
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Ebola Virus Glycoprotein Strongly Binds to Membranes in the Absence of Receptor Engagement

Vaknin, A. et al.
2024
ACS Infect. Dis.
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Mechanobiology
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Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis

Kural, M. H. et al.
2024
Cell Death & Disease
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Mechanobiology
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Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells

Winer, B. Y. et al.
2024
Science Immunology
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Mechanobiology
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Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps

Jawerth, L. et al.
2018
Physical Review Letters
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Phase Separation
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Molecular Crowding Tunes Material States of Ribonucleoprotein Condensates

Kaur, T. et al.
2019
Biomolecules
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Phase Separation
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Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

Gui, X., et al.
2019
Nature Communications
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Phase Separation
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Protein condensates as aging Maxwell fluids

Jawerth, L. et al.
2020
Science
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Phase Separation
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Interplay between Short-Range Attraction and Long-Range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein–RNA Complexes

Alshareedah, I. et al.
2019
Journal of the American Chemical Society
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Phase Separation
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Phase transition of RNA−protein complexes into ordered hollow condensates

Alshareedah, I. et al.
2020
PNAS
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Phase Separation
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A Minimal Load-and-Lock Ru Luminescent DNA Probe

Newton, M. D. et al.
2021
Angew. Chem. Int. Ed.
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Phase Separation
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Determinants for Fusion Speed of Biomolecular Droplets

Ghosh, A. and Zhou, H.-X.
2020
J. Phys. Chem. B
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Phase Separation
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Quantifying Viscosity and Surface Tension of Multi-Component Protein-Nucleic Acid Condensates

Alshareedah, I. et al.
2021
Biophysical Journal
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Phase Separation
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Sequence-encoded and Composition-dependent Protein-RNA Interactions Control Multiphasic Condensate Morphologies

Kaur, T. et al.
2021
Nature Communications
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Phase Separation
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Single-molecule and ensemble methods to probe RNP nucleation and condensate properties

Rhine, K. et al.
2021
Methods
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Phase Separation
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Direct visualization of the effect of DNA structure and ionic conditions on HU–DNA interactions

Lin, SN. et al.
2021
Scientific Reports
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Phase Separation
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F/YGG-motif is an intrinsically disordered nucleic-acid binding motif

Joris Van Lindt et al.,
2022
RNA biology
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Phase Separation
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Shear relaxation governs fusion dynamics of biomolecular condensates

Ghosh, A. et al.
2021
Nature Communications
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Phase Separation
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Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides

Alshareedah, I. et al.
2021
Nature Communications
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Phase Separation
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Controlling synthetic membraneless organelles by a red-light-dependent singlet oxygen-generating protein

Manjia Li. et al,
2022
Nature Communications
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Phase Separation
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Macromolecular Regulation of the Material Properties of Biomolecular Condensates

Kota, D, et al.
2022
J. Phys. Chem. Lett.
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Phase Separation
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Bloom syndrome helicase compresses single-stranded DNA into phase-separated condensates

Teng, Wang.et al.
2022
Angew. Chem. Int. Ed.
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Phase Separation
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Extreme dynamics in a biomolecular condensate

Galvanetto, N. et al.
2023
Nature Communications
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Phase Separation
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Targeted perturbation of signaling-driven condensates

Gui, T. et al.
2023
Molecular Cell
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Phase Separation
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Adenosine Triphosphate Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks

Kota D. et al.,
2024
JACS
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Phase Separation
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RNAs undergo phase transitions with lower critical solution temperatures

Wadsworth, G.M. et al.,
2023
Nature Chemistry
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Phase Separation
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Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex

Zhao, Y. et al.
2024
Nucleic Acids Research
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Phase Separation
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Determinants of viscoelasticity and flow activation energy in biomolecular condensates

Alshareedah, I. et al.,
2024
Science Advances
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Phase Separation
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Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates

Alshareedah, I. et al.
2024
Nature Physics
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Phase Separation
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Viscoelastic properties of vimentin originate from nonequilibrium conformational changes

Block, J.et al.
2018
Science Advances
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Cytoskeletal Structure and Transport
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Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain

Block, J. et al.
2017
Physical Review Letters
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Cytoskeletal Structure and Transport
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Vimentin Intermediate Filaments Undergo Irreversible Conformational Changes during Cyclic Loading

Forsting, J. et al.
2019
Nano Letters
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Cytoskeletal Structure and Transport
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Lateral Subunit Coupling Determines Intermediate Filament Mechanics

Lorenz, C. et al.
2019
Physical Review Letters
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Cytoskeletal Structure and Transport
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Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct

Schaedel, L. et al.
2021
Interactions Nature Communications
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Cytoskeletal Structure and Transport
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Pathogenic Mutations in the Kinesin-3 Motor KIF1A Diminish Force Generation and Movement Through Allosteric Mechanisms

Budaitis, B. G. et al.
2021
Journal of Cell Biology
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Cytoskeletal Structure and Transport
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The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation

Zhang, Q. et al.
2019
Science Advances
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Cytoskeletal Structure and Transport
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A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules

Gutierrez-Escribano, et al.
2019
Science Advances
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Cytoskeletal Structure and Transport
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Synaptotagmin-1 and Doc2b Exhibit Distinct Membrane-Remodeling Mechanisms

Sorkin, R. et al.
2020
Biophysical Journal
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Cytoskeletal Structure and Transport
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Tuning intermediate filament mechanics by indirect and direct charge variations

Schepers, A. et al.
2020
Nanoscale
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Cytoskeletal Structure and Transport
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Molecular mechanism for direct actin force-sensing by α-catenin

Mei, L. et al.
2020
eLife
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Cytoskeletal Structure and Transport
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Post-Translational Modifications Soften Vimentin Intermediate Filaments

Kraxner, J. et al.
2020
Nanoscale
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Cytoskeletal Structure and Transport
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A Highly Conserved 310-Helix Within the Kinesin Motor Domain is Critical for Kinesin Function and Human Health

Lam, A. J. et al.
2021
Science Advances
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Cytoskeletal Structure and Transport
Publication
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The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Zimmer, M. M. et al.
2021
Nature Communications
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Protein Folding
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Anillin propels myosin-independent constriction of actin rings

Kučera, O. et al.
2021
Nature Communications
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Cytoskeletal Structure and Transport
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Multiscale mechanics and temporal evolution of vimentin intermediate filament networks

Schepers, A. V. et al.
2021
PNAS
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Cytoskeletal Structure and Transport
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Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules

Muir, K. W. et al.
2023
Science
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Cytoskeletal Structure and Transport
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Kinesin-1-transported liposomes prefer to go straight in 3D microtubule intersections by a mechanism shared by other molecular motors

Bensel, B.M. et al.
2024
PNAS
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Cytoskeletal Structure and Transport
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Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes

Liu, X. et al.
2024
Nature Communications
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Cytoskeletal Structure and Transport
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Processive extrusion of polypeptide loops by a Hsp100 disaggregase

Avellaneda, M. et al.
2020
Nature Communications
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Protein Folding
Publication
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Simultaneous sensing and imaging of individual biomolecular complexes enabled by modular DNA–protein coupling

Avellaneda, M. et al.
2020
Communications Chemistry
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Protein Folding
Publication
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Facile tethering of stable and unstable proteins for optical tweezers experiments

Maciuba, K. et al.
2021
Biophysical Journal
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Protein Folding
Publication
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The ribosome modulates folding inside the ribosomal exit tunnel

Wruck, F. et al.
2021
Communications Biology
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Protein Folding
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Optical Tweezers to Study RNA-Protein Interactions in Translation Regulatio

Pekarek L et al.,
2022
JoVE
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Protein Folding
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Minimalist design of polymer-oligopeptide hybrid as intrinsically disordered protein-mimicking scaffold for artificial membraneless organelle

Liu, J. et al.
2022
ACS Cent. Sci.
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Protein Folding
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Protein chain collapse modulation and folding stimulation by GroEL-ES

Naqvi, M. et al.
2022
Science Advances
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Protein Folding
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POTATO: An automated pipeline for batch analysis of optical tweezers data

Buck, S. et al.
2022
Biophysical Journal
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Protein Folding
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Single-molecule experiments reveal the elbow as an essential folding guide in SMC coiled-coil arms

Freitag M. et al.,
2022
Biophysical Journal
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Protein Folding
Publication
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The activated ClpP peptidase forcefully grips a protein substrate

Walker, S. D. et al,
2022
Biophysical Journal
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Protein Folding
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Single-molecule force spectroscopy of toehold-mediated strand displacement

Walbrun, A. et al.
2024
Nature Communications
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Protein Folding
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Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function

Pekarek L. et al.,
2022
NAR
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Protein Folding
Publication
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Mechanistic Insights into the Folding Mechanism of Region V in Ice-Binding Protein Secreted by Marinomonas primoryensi Revealed by Single-Molecule Force Spectroscopy

Wang, H. et al.
2023
Langmuir
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Protein Folding
Publication
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A molecular optomechanics approach reveals functional relevance of force transduction across talin and desmoplakin

Sadhanasatish, T et al
2023
Science Advances
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Protein Folding
Publication
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Cytosolic Interactome Protects Against Protein Unfolding in a Single Molecule Experiment

Scalvini, B. et al.
2023
Advanced Biology
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Protein Folding
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Free-energy measuring nanopore device

Momčilo Gavrilov et al.
2023
Physical Review E
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Protein Folding
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Aha1 regulates Hsp90’s conformation and function in a stoichiometry-dependent way

Mondol, T. et al.
2023
Biophysical Journal
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Protein Folding
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Membrane-induced 2D phase separation of the focal adhesion protein talin

Litschel, T. et al.
2024
Nature Communications
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Protein Folding
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Probing the stability and interdomain interactions in the ABC transporter OpuA using single-molecule optical tweezers

Van Der Sleen, L. et al.
2024
Cell Reports
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Protein Folding
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Stick-slip unfolding favors self-association of expanded HTT mRNA

O’Brien, B. M. et al.
2024
Nature Communications
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Protein Folding
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Human RPA activates BLM’s bidirectional DNA unwinding from a nick

Qin, Z. et al.
2020
eLife
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DNA-Binding proteins
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DNA stretching induces Cas9 off-target activity

Newton, M. et al.
2019
Nature Structural & Molecular Biology
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DNA Editing
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Reversible histone glycation is associated with disease-related changes in chromatin architecture

Zheng, Q. et al.
2019
Nature Communications
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DNA-Binding proteins
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Sites of high local frustration in DNA origami

Kosinski R. et al.
2019
Nature Communications
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DNA-Binding proteins
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Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase

Wasserman, M. et al.
2019
Cell
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DNA Replication
Publication