Avidion
The next generation Cell Avidity platform
Ideal for cell therapy candidate screening and large characterization studies. Run up to 4 disposable 48-well cartridges a day for a total of 192 measurements with <80 min. hands-on time.
Part of:
High throughput measurements with 96-well plate compatibility
Minimal hands-on time through automated handling and deep-learning analysis
Multiplexed insights through 4-color fluorescence readouts
Launch video
Ready for lift-off
Get to know Avidion by watching our brand new launch video.
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Platform
Take a look inside
Discover the advanced technology and engineering that makes Avidion possible
Liquid handling system
Automatically manages media exchanges and reagent additions, ensuring consistent and reproducible biology.
Centrifuge
Gently applies a controlled force to assess multi-receptor binding, distinguishing strong interactions from weaker ones.
Incubator
Ensures optimal conditions for your target cells in preparation for your experiment.
Multicolor fluorescence imaging
Unlocks multiplex imaging and enables unified experiments including cell population phenotyping, receptor expression, and transduction efficiency.
Deep-learning enabled graphical processing
Delivers exceptional data quality through automated, intelligent quantification, ready for you right after your experiment.
Robotic cartridge handling
Seamlessly moves your cells through all of the Avidion's compartments, delivering near hands-free operation.
Highlighted capabilities
Dive into some of the Avidion’s capabilities for yourself
How many Cell Avidity measurements can you do in a day? A good example is a CAR-T cell screening project performed in collaboration with Professor Dirk Busch at Technical University Munich, using Avidion. In just half a day, it is possible to test and rank 20 CAR constructs.
Rapid screening
20 Jurkat CAR constructs screened in a single day. Each sample was measured with 4 technical replicates.
Cost & time efficiency
Early, robust identification of top candidates
Repeatable and reproducible results
Tight error bars and SDs confirm assay robustness
Avidion offers 3 complimentary fluorescent channels to assess various markers alongside Cell Avidity, enhancing dimensionality and providing deeper insights into effector cell–target interactions.
1 (Right) Having multiple fluorescent channels enables multiplexing with different markers. For this demonstration, Jurkat cells on Nalm6 were kept too long in culture medium to create artificially high concentrations of dead cells.
Workflow
High throughput & hands-off
Introduce your target cells
Load up to 4 cartridges of target cells, adherent or non-adherent, using standard 96-well plates. Avidion automatically transfers the cells and ensures proper incubation through various checks.
Add your media and effector cells
Introduce your fluorescently labeled effector cells in a separate 96-well plate. Avidion automatically introduces them to your target cells.
Automated Cell Avidity measurements
After the right incubation time, the measurements automatically begin. With a gentle centrifugal force and all the necessary multicolor images, true cell binding is revealed.
View your results and sign off for the day
Get direct access to Cell Avidity insights thanks to Avidion's on-board analysis. With disposable cartridges and automated cleaning, you can shift your focus to your next experiment.
Software
Your new data acquisition and analysis software
Design, execute and analyze your experiment with ease and confidence. Our software delivers an intuitive experience combined with powerful algorithms for the most complex binding behavior.
Design and prep for your experiment with ease
Design the perfect experiment with our intuitive UI. You’ll receive a lear overview of experiment phases, reagents and well plate layouts.
Enjoy an automated workflow with minimal hands-on time
Enjoy a guided experience with clear actions and information presented throughout your whole experiment.
Obtain immediate insights and study them wherever, whenever
Your data is ready straight after the experiment. Study and analyze it from the comfort of your desk, or home.
Key content
Discover all the details
Avidion Product Brochure
Product Brochure
The latest all-in-one overview of our Avidion solution.
Benefits
Beyond the product
Take a look at the perks that come with being one of our users
Symposia
Join the community
BIT (Breakthroughs in Immunology) is LUMICKS’ symposia format. We regularly host events across the world, aiming to bring together scientists interested in Cell Avidity applications to share their research, connect, and exchange ideas and experiences.
Begin your LUMICKS journey
Demonstrating value
Our application scientists can help create interest among potential users through organizing different events such as seminars, workshops, and demonstrations, as well as meet with stakeholders individually to understand and help solve their needs.
Avidigo services
At our Amsterdam headquarters, our internal Avidigo service team supports academic and industry clients looking to integrate Cell Avidity into their workflows and pipeline. From experimental design to data analysis and interpretation, we support you all the way.
Are you looking to gain proof before applying Cell Avidity?
Grant & tender support
Throughout our history we have supported multiple successful grants across a broad spectrum of funding and users involved. Our application scientists are experienced in highlighting the unique value of Cell Avidity and its solutions.
To this end, we have a dedicated grant expeditor brochure that indicates all the possibilities and provides a clear outline of the type of processes we can help you go through. Please contact us to gain more information!
To this end, we have a dedicated grant expeditor brochure that indicates all the possibilities and provides a clear outline of the type of processes we can help you go through. Please contact us to gain more information!
Let’s get in touch
Our team is standing by to help you
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Text Link
Identification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma
Chaturantabut, S. et al.
2025
J. Clin. Investigation
https://www.jci.org/articles/view/182417
Publication
Text Link
Rational Chemical and Genetic Modifications Enhance Avidity and Function of CD70-Directed CAR T Cells for Myeloid Leukemia
Leick, M. B. et al.
2022
Cancer Cell
https://doi.org/10.1016/j.ccell.2022.04.001
Publication
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Button Text
Improving CAR-T immunotherapy for lymphoma by fine-tuning avidity
Webinar
July 16, 2024
01-01-20
Commercial CAR-T therapies still suffer from severe limitations, as majority of patients fail to achieve complete response and ultimately relapse.
Watch this Webinar to discover Prof. Marco Ruella’s team have adopted a novel CAR-T avidity screening method to improve safety and exhaustion profile, leading to 100% clinical response in a phase I trial.
Text Link
Enhancing efficacy against clear cell renal cell carcinoma through format-tuning of bispecific T cell engagers
Scientific update
January 29, 2025
01-01-20
Cell Avidity: a key to accelerate IND filing in cell therapy drug development
Whitepaper
July 1, 2023
01-01-20
Cell Avidity measures true binding of biparatopic antibodies
Application note
April 23, 2025
01-01-20
Mechanistic issues limit the effectiveness of many current cancer-targeting antibody therapies, with monospecific antibodies often hindered by receptor dimerization and activation. Biparatopic antibodies, which bind to two unique non-overlapping epitopes, offer a promising solution with stronger binding, more potent antagonism, and higher specificity.
Avidigo Service Brochure
Brochure
May 1, 2025
01-01-20
SITC 2025
Conference
April 22, 2025
01-01-20
CAR-TCR Summit 2025
Conference
April 22, 2025
01-01-20
CICON 2025
Conference
April 22, 2025
01-01-20
See more. Know more.
We empower the academic and pharmaceutical communities with cutting-edge technologies to deeply understand the mechanisms of life and disease, driving the discovery and development of life-saving therapies
All products and technologies are for Research Use Only (RUO) except when specifically noted