Publications
Dynamic Single-Molecule
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Bloom syndrome helicase compresses single-stranded DNA into phase-separated condensates
Wang, T. et al.
2022
Angew. Chem. Int. Ed.
Extreme dynamics in a biomolecular condensate
Galvanetto, N. et al.
2023
Nature Communications
Targeted perturbation of signaling-driven condensates
Gui, T. et al.
2023
Molecular Cell
Adenosine Triphosphate Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks
Kota, D. et al.
2024
JACS
RNAs undergo phase transitions with lower critical solution temperatures
Wadsworth, G. M. et al.,
2023
Nature Chemistry
Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex
Zhao, Y. et al.
2024
Nucleic Acids Research
Determinants of viscoelasticity and flow activation energy in biomolecular condensates
Alshareedah, I. et al.
2024
Science Advances
Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates
Alshareedah, I. et al.
2024
Nature Physics
Viscoelastic properties of vimentin originate from nonequilibrium conformational changes
Block, J. et al.
2018
Science Advances
Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain
Block, J. et al.
2017
Physical Review Letters
Vimentin Intermediate Filaments Undergo Irreversible Conformational Changes during Cyclic Loading
Forsting, J. et al.
2019
Nano Letters
Lateral Subunit Coupling Determines Intermediate Filament Mechanics
Lorenz, C. et al.
2019
Physical Review Letters
Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct
Schaedel, L. et al.
2021
Interactions Nature Communications
Pathogenic Mutations in the Kinesin-3 Motor KIF1A Diminish Force Generation and Movement Through Allosteric Mechanisms
Budaitis, B. G. et al.
2021
Journal of Cell Biology
The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation
Zhang, Q. et al.
2019
Science Advances
A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules
Gutierrez-Escribano, P. et al.
2019
Science Advances
Synaptotagmin-1 and Doc2b Exhibit Distinct Membrane-Remodeling Mechanisms
Sorkin, R. et al.
2020
Biophysical Journal
Tuning intermediate filament mechanics by indirect and direct charge variations
Schepers, A. V. et al.
2020
Nanoscale
Molecular mechanism for direct actin force-sensing by α-catenin
Mei, L. et al.
2020
eLife
Post-Translational Modifications Soften Vimentin Intermediate Filaments
Kraxner, J. et al.
2020
Nanoscale
A Highly Conserved 310-Helix Within the Kinesin Motor Domain is Critical for Kinesin Function and Human Health
Lam, A. J. et al.
2021
Science Advances
The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting
Zimmer, M. et al.
2021
Nature Communications
Anillin propels myosin-independent constriction of actin rings
Kučera, O. et al.
2021
Nature Communications
Multiscale mechanics and temporal evolution of vimentin intermediate filament networks
Schepers, A. V. et al.
2021
PNAS
Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules
Muir, K. W. et al.
2023
Science
Kinesin-1-transported liposomes prefer to go straight in 3D microtubule intersections by a mechanism shared by other molecular motors
Bensel, B. M. et al.
2024
PNAS
Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes
Liu, X. et al.
2024
Nature Communications
Processive extrusion of polypeptide loops by a Hsp100 disaggregase
Avellaneda, M. et al.
2020
Nature Communications
Simultaneous sensing and imaging of individual biomolecular complexes enabled by modular DNA–protein coupling
Avellaneda, M. et al.
2020
Communications Chemistry
Facile tethering of stable and unstable proteins for optical tweezers experiments
Maciuba, K. et al.
2021
Biophysical Journal
The ribosome modulates folding inside the ribosomal exit tunnel
Wruck, F. et al.
2021
Communications Biology
Optical Tweezers to Study RNA-Protein Interactions in Translation Regulatio
Pekarek, L. et al.
2022
JoVE
Minimalist design of polymer-oligopeptide hybrid as intrinsically disordered protein-mimicking scaffold for artificial membraneless organelle
Liu, J. et al.
2022
ACS Cent. Sci.
Protein chain collapse modulation and folding stimulation by GroEL-ES
Naqvi, M. et al.
2022
Science Advances
POTATO: An automated pipeline for batch analysis of optical tweezers data
Buck, S. et al.
2022
Biophysical Journal
Single-molecule experiments reveal the elbow as an essential folding guide in SMC coiled-coil arms
Freitag, M. et al.
2022
Biophysical Journal
The activated ClpP peptidase forcefully grips a protein substrate
Walker, S. D. et al.
2022
Biophysical Journal
Single-molecule force spectroscopy of toehold-mediated strand displacement
Walbrun, A. et al.
2024
Nature Communications
Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function
Pekarek, L. et al.
2022
NAR
Mechanistic Insights into the Folding Mechanism of Region V in Ice-Binding Protein Secreted by Marinomonas primoryensi Revealed by Single-Molecule Force Spectroscopy
Wang, H. et al.
2023
Langmuir
A molecular optomechanics approach reveals functional relevance of force transduction across talin and desmoplakin
Sadhanasatish, T. et al.
2023
Science Advances
Cytosolic Interactome Protects Against Protein Unfolding in a Single Molecule Experiment
Scalvini, B. et al.
2023
Advanced Biology
Free-energy measuring nanopore device
Gavrilov, M. et al.
2023
Physical Review E
Aha1 regulates Hsp90’s conformation and function in a stoichiometry-dependent way
Mondol, T. et al.
2023
Biophysical Journal
Membrane-induced 2D phase separation of the focal adhesion protein talin
Litschel, T. et al.
2024
Nature Communications
Probing the stability and interdomain interactions in the ABC transporter OpuA using single-molecule optical tweezers
Van Der Sleen, L. et al.
2024
Cell Reports
Stick-slip unfolding favors self-association of expanded HTT mRNA
O’Brien, B. M. et al.
2024
Nature Communications
Human RPA activates BLM’s bidirectional DNA unwinding from a nick
Qin, Z. et al.
2020
eLife
DNA stretching induces Cas9 off-target activity
Newton, M. D. et al.
2019
Nature Structural & Molecular Biology
Reversible histone glycation is associated with disease-related changes in chromatin architecture
Zheng, Q. et al.
2019
Nature Communications
Sites of high local frustration in DNA origami
Kosinski, R. et al.
2019
Nature Communications
Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase
Wasserman, M. et al.
2019
Cell
Real-Time Assembly of Viruslike Nucleocapsids Elucidated at the Single-Particle Level
Marchetti, M. et al.
2019
Nano Letters
Single-Molecule Mechanics in Ligand Concentration Gradient
Kretzer, B. et al.
2020
Micromachines
Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin
Leicher, R. et al.
2019
PNAS
Cooperative DNA looping by PRC2 complexes
Lin, X. et al.
2021
Nucleic Acids Research
Alkyltransferase-like protein clusters scan DNA rapidly over long distances and recruit NER to alkyl-DNA lesions
Rill, N. et al.
2020
PNAS
Distinct pre-initiation steps in human mitochondrial translation
Khawaja, A. et al.
2020
Nature Communications
Constructing arrays of nucleosome positioning sequences using Gibson Assembly for single-molecule studies
Spakman, D. et al.
2020
Scientific Reports
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins
Belan, O. et al.
2021
Molecular Cell
Dynamics of Staphylococcus aureus Cas9 in DNA target Association and Dissociation
Zhang, S. et al.
2020
EMBO Rep
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
Keenen, M. M. et al.
2021
eLife
Proximal Single-Stranded RNA Destabilizes Human Telomerase RNA G-Quadruplex and Induces Its Distinct Conformers
Ye, S. et al.
2021
J. Phys. Chem. Lett.
Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis
Belan, O. et al.
2021
STAR Protocols
Mechanics of CRISPR-Cas12a and engineered variants on λ-DNA
Paul, B. et al.
2021
Nucleic Acids Research
Force generation by protein–DNA co-condensation
Quail, T. et al.
2021
Nature Physics
Elucidating the Role of Topological Constraint on the Structure of Overstretched DNA Using Fluorescence Polarization Microscopy
Backer, A. S. et al.
2021
J. Phys. Chem. B
CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS
de Asis Balaguer, F. et al.
2021
eLife
Efficient DNA interrogation of SpCas9 governed by its electrostatic interaction with DNA beyond the PAM and protospacer
Zhang, Q. et al.
2021
Nucleic Acids Research
Virus self-assembly proceeds through contact-rich energy minima
Buzón, P. et al.
2021
Science Advances
Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch
Hill, C. H. et al.
2021
Nature Communications
DNA replication origins retain mobile licensing proteins
Sánchez, H. et al.
2021
Nature Communications
Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA
Hormeno, S. et al.
2022
eLife
HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51
Anand, R. et al.
2021
Nature Communications
Cas12a Target Search and Cleavage on Force-Stretched DNA
Losito, M. et al.
2021
PCCP
CENP-B-mediated DNA loops regulate activity and stability of human centromeres
Chardon, F. et al.
2022
Molecular Cell
Co-condensation of proteins with single- and double-stranded DNA
Renger, R. et al.
2022
PNAS
HIV-1 Nucleocapsid Protein Binds Double-Stranded DNA in Multiple Modes to Regulate Compaction and Capsid Uncoating
Gien, H. et al.
2022
Viruses
Identification of the target and mode of action for the prokaryotic nucleotide excision repair inhibitor ATBC
Bernacchia, L. et al.
2022
Biosci Rep
Sequence-dependent surface condensation of a pioneer transcription factor on DNA
Morin, J. A. et al.
2022
Nature Physics
The convergence of head-on DNA unwinding forks induces helicase oligomerization and activity transition
Bi, L. et al.
2022
PNAS
Resolving the subtle details of human DNA alkyltransferase lesion search and repair mechanism by single-molecule studies
Kono, S. et al.
2022
PNAS
Rtt105 regulates RPA function by configurationally stapling the flexible domains
Kuppa, S. et al.
2022
Nature Communications
Stochastically multimerized ParB orchestrates DNA assembly as unveiled by single-molecule analysis
Guo, L. et al.
2022
Nucleic Acids Research
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
Li, S. et al.
2022
Nature Communications
Origin recognition complex harbors an intrinsic nucleosome remodeling activity
Li, S. et al.
2022
PNAS
ATP Binding Facilitates Target Search of SWR1 Chromatin Remodeler by Promoting One-Dimensional Diffusion on DNA
Carcamo, C. C. et al.
2022
eLife
Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE)
Schaich, M. et al.
2023
NAR
Search and processing of Holliday junctions within long DNA by junction-resolving enzymes
Kaczmarczyk, A. et al.
2022
Nature Communications
Smc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures
Chang, J. T-H. et al.
2022
Nature Communications
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination
Wang, L. et. al.
2023
Molecular Cell
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
Belan, O. et al.
2022
Molecular Cell
PICH acts as a force dependent nucleosome remodeler
Spakman, D. et al.
2022
Nature Communications
Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity
Wan, L. et al.
2023
PNAS
Cooperative interaction between AAG and UV-DDB in the removal of modified bases
Jang, S. et al.
2022
NAR
Single-Molecule Force Spectroscopy of Deoxyribonucleic Acid and Deoxyribonucleic Acid Polymerase Activity Impacted by Alkylating Agents
Cai, T. et al.
2023
J. Phys. Chem. Lett.
Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes
McCauley, M. et al.
2022
Cell Reports
Stabilization of DNA fork junctions by Smc5/6 complexes revealed by single-molecule imaging
Tanasie, N-L. et al.
2022
Cell Reports
Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation
Montero, D. R. et al.
2023
Nature Communications
Establishment of dsDNA-dsDNA interactions by the condensin complex
Tang, M. et al.
2023
Molecular Cell
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