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Congratulations to Dr. Samuel Katz, Recipient of the LUMICKS Cell Avidity Travel Award

We are delighted to announce that Samuel Katz, MD, PhD from Yale School of Medicin has been selected as the recipient of the LUMICKS 2026 SITC Cell Avidity Travel Award.

Dr. Katz was recognized for their innovative research leveraging Cell Avidity measurements to better understand CAR-T Therapy in Solid Tumors. Their work will be presented at SITC 2026 Annual Meeting, where they will share new insights with the scientific community.

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Poster Title: Nanobody engineering overcomes key barriers to MET CAR-T cell therapy in solid tumors

Abstract Number: 128

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The LUMICKS Cell Avidity Travel Award supports researchers who are advancing Cell Avidity science and helping expand our understanding of immune cell function, cell therapies, and therapeutic development.

Congratulations, Dr. Samuel Katz, and thank you for advancing Cell Avidity research!

“Cell Avidity profiling with the LUMICKS z-Movi system allowed us to directly measure the physical binding strength between our nanobody CAR-T constructs and tumor target cells. We found that avidity did not correlate linearly with cytotoxic potency. The highest-avidity constructs did not mediate the strongest tumor killing, suggesting that avidity above a certain functional threshold is sufficient, while further increases may not improve and could even reduce killing efficiency. Overall, avidity profiling added a valuable biophysical dimension to our multi-platform characterization of CAR-T function, complementing our cytotoxicity and cytokine assays.”

Samuel Katz, MD, PhD
Yale School of Medicine

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